The city Dera Ghazi Khan was founded at the close of 15th century and named after the name of a Baloch sardar, Nawab Ghazi Khan. In 1908 the original town which was located at a distance of 10 kilometers
from the present city was destroyed due to a flash flood by heavy rains over flowing the river Indus. The present city was established in 1910. It is situated on the west bank of river Indus. The economy of the area is mainly based on agriculture and the prominent crops are cotton, wheat and sugarcane. Sheep and Goat farming is also being practiced in the surrounding population units. Recently, a good number of industrial units have also been established.

The students belonging to this remote part of southern Punjab felt deprived from getting quality education as there was no standard institution in this city. Keeping in view the dire need of the students, the management of Punjab Colleges, established an institution in Dera Ghazi Khan. The Punjab College, Dera Ghazi Khan is located near Board of Intermediate and Secondary Education building. The college is housed in a spacious campus. The classrooms are air-conditioned to facilitate the students in term of their peaceful learning environment. The computer and science laboratories are furnished with the latest equipment to strengthen the practical skills of the students. Teaching in Biology, Chemistry, Physics and Mathematics is supplemented with content-based three dimensional animations to develop knowledge-based learning habits. The library is well stocked              with the latest books pertaining to various disciplines. The faculty is highly qualified, with rich experience in teaching of their respective subjects. The College is affiliated with the Board of Intermediate and Secondary Education, Dera Ghazi Khan.